Endocrine Abstracts

The growth hormone (GH) receptor is a key regulator of cellular metabolism. Using model cell systems we have investigated how GH-induced signaling is regulated, both in paracrine and autocrine conditions.Three features render GHR unique: (a) an active ubiquitination system is required for both endocytosis and degradation in lysosomes; (b) uptake of receptor is a continuous process, independent of GH binding and Jak2 signal transduction; (c) only cell sur...